Allerinol Clinical Evidence

Experimental Biology and Medicine

Takano H et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. 2004 Mar;229(3):247-54.

Can Perilla frutescens enriched with rosmarinic acid alleviate allergy symptoms?

Perilla frutescens enriched with rosmarinic acid, a polyphenolic phytochemical, has been found to suppress allergic reactions and inflammation in mice, but few placebo-controlled studies have studied the effect of polyphenolic phytochemicals on allergies in humans.

Study Type:
Human clinical intervention trial.

Study Design:
Randomized, double-blind, age-matched, placebo-controlled, parallel group study. Subjects took either a daily dose of Perilla frutescens enriched with rosmarinic acid or a placebo and kept a daily symptoms journal. Researchers took samples of nasal fluid and blood, measured levels of substances involved in allergic or immune responses (such as infiltrating cells and concentrations of eotaxin, IL-beta, IL-8, and histamine), and ran routine tests on the blood.

29 patients with mild seasonal allergic rhinoconjunctivitis (SAR)

50 mg or 200 mg for 21 days

Subjects reported improvements in itchy nose, watery eyes, and itchy eyes, as well as in total symptoms. Treatment significantly reduced neutrophils and eosinophils (two types of white blood cells) in nasal lavage fluid.

“…[E]xtract of Perilla frutescens enriched for rosmarinic acid can be an effective intervention for mild SAR… Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.”


Allerinol, a proprietary extract of the Japanese herbPerilla frutesensenriched with rosmarinic acid, reduces inflammation of the nasal passageways by suppressing allergic antibody responses. Research has shown that Allerinol significantly decreases the number of neutrophils and eosinophils — white blood cells that cause tissue to break down and that contribute to inflammation — found in nasal mucus.Rosmarinic acid, a component of Allerinol, has also been shown to inhibit the release of histamine, which accounts for its ability to relieve itchy, watery eyes.