Juvecol® Clinical Evidence
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
Tatsuji T, et al. Ingestion of Salmon Nasal Cartilage-Derived Proteoglycan Improves Skin Condition: A Randomized, Double-Blind, Controlled Study. 2015;15:160-167.
What are the effects of salmon nasal cartilage-derived proteoglycan (salmon PG) on the skin?
Present in all tissues, including the skin and joints, the extracellular matrix (ECM) provides the physical scaffolding for the surrounding cells. Degradation of the ECM, which occurs with aging, impairs skin structure and function. Can supplementing with proteoglycans, which are key components of the ECM, help restore youthfulness to aging skin?
Human intervention clinical trial
Randomized, placebo-controlled, double-blind. Participants were randomly assigned to take either 5 mg salmon PG or placebo daily. Skin condition was evaluated by measuring skin elasticity, wrinkles, pore condition, and blotches and by analyzing the corneum (the outer layer of the skin) and skin moisture levels.
5 mg/day for 2 weeks
19 men and women, aged 40-54
Salmon PG significantly improved skin elasticity and reduced the number of undereye wrinkles compared to placebo. Participants who took salmon PG also experienced reductions in skin looseness, conspicuous or darkened pores, and number of blotches compared to baseline levels. Salmon PG also improved skin moisture and roughness versus baseline.
“Our results suggest the potential of sPG as a food ingredient to improve human skin condition, including skin elasticity, wrinkles, facial pores, blotches, moisture, and smoothness.”
Journal of Agricultural and Food Chemistry
Najima M, et al. Usefulness of the supplement containing proteoglycan for Japanese healthy people feeling knee’s discomfort. 2016;53(3):64-71.
Can salmon PG improve knee discomfort in healthy people?
Age-related changes in the extracellular matrix (ECM) of cartilage, which contains various types of collagen and proteoglycan, contribute to the development of osteoarthritis. Can supplemental PG help?
Human clinical intervention trial
Randomized, placebo-controlled, double-blind. Participants were randomly divided into two groups: the treatment group, which received salmon PG daily, and the placebo group, which received placebo tablets. Pain VAS (measuring pain while lying down, walking, and going up and down stairs), range of motion, and modified J-KOOS (measuring stiffness, pain, function, and quality of life) were assessed at baseline and at 4, 8, and 12 weeks.
10 mg/day for 12 weeks
31 healthy people, between the ages of 40 and 69, experiencing knee discomfort
Pain VAS: Knee pain improved significantly from baseline among participants taking salmon PG. Comparing the salmon PG group to the placebo group, there was a statistically significant difference in pain upon climbing up and down stairs.
Range of motion: Knee extension and flexion improved significantly in the salmon PG group compared to baseline after 4, 8, and 12 weeks of ingestion. There were also significant improvements in knee extension and flexion in the salmon PG group versus the placebo group after 12 weeks.
Modified J-KOOS: All four indices evaluated — stiffness, pain, function, and quality of life — showed improvement among those taking salmon PG versus those taking placebo.
“It is suggested that the ingestion of the supplement containing proteoglycan by Japanese healthy people feeling knee’s discomfort for 12 weeks contributed to improving the joint support.”
Experimental and Therapeutic Medicine
Tomonaga, et al. Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double-blind placebo-controlled clinical study. 2017 Jul;14(1):115-126.
Can salmon PG exert a protective effect on cartilage cells in joints among people with knee discomfort?
A previous open-label study by the same authors found that salmon PG alleviates symptoms of osteoarthritis, possibly by reducing the degradation of type II collagen. Can the results be replicated in a controlled clinical trial?
Human clinical intervention trial
Randomized, placebo-controlled, double-blind, parallel group. Participants were randomly assigned to receive either salmon PG or placebo. Researchers measured markers for type II collagen degradation (C1, C2) and synthesis (PIICP), as well as the ratio between the two, at baseline and at 16 weeks.
10 mg/day for 16 weeks
55 men and women (average age 52.4 years) with knee discomfort but without diagnosis of knee osteoarthritis
Among participants with either high levels of knee pain and physical dysfunction or constant knee pain in the salmon PG group, there was a significant change in C1, C2 levels compared with those in the placebo group after 16 weeks of intervention. The C1, 2C/PIICP ratios decreased in the salmon PG group (meaning less collagen degradation to more collagen synthesis), while they increased slightly in the placebo group (meaning more collagen degradation to less collagen synthesis).
“Therefore, oral administration of salmon nasal cartilage proteoglycan at a dose of 10 mg/day may exert a chondroprotective action in subjects with knee joint discomfort. This effect was achieved by improving cartilage metabolism (reducing type II collagen degradation and enhancing type II collagen synthesis), without causing apparent adverse effects.”