Tocotrienols Clinical Evidence
Can supplementation with tocotrienols reduce DNA damage?
Tocotrienols are a form of vitamin E, one of the body’s primary antioxidants. Antioxidants protect the body against the physiological deterioration associated with aging by scavenging free radicals. Are tocotrienols effective for this purpose?
Human clinical intervention trial
Randomized, placebo-controlled, double-blind. Subjects took tocotrienols (as Tri E Tocotrienol) or a placebo and their blood was analyzed for DNA damage. Urine samples were also analyzed.
64 subjects, aged 37-78
160 mg/day for 6 months
DNA damage was significantly reduced at 3 months and maintained that level at 6 months. Sister chromatid exchanges (a kind of genetic mutation) were reduced at 6 months, especially in the subjects aged 50 and older. Urinary 8-OHdG (a marker of oxidative stress excreted in urine) levels were also significantly reduced.
In subjects taking the higher dose, lemon balm alleviated the negative mood induced by the test. These subjects’ self-ratings of calmness were significantly higher than other subjects’. Additionally, subjects taking the lower dose were significantly faster at the test, with no loss of accuracy. Tri E Tocotrienol supplementation may be beneficial by reducing DNA damage as indicated by a reduction in DNA damage, SCE frequency, and urinary 8-OHdG.